A thorough history it important to identify those at high risk including smokers.  Clinically, a full Ear Nose and Throat and Neck examination including a flexible nasopharyngolaryngoscopy would help identify or exclude secondary disease.  Once a working diagnosis has been achieved, further investigations may be warranted including Barium Swallows, Oesophagoscopy X-Rays, Ultrasounds and CT scans.  In the commonest form, which is the primary Globus, special investigations are usually not needed pending the outcome of therapy.